TürkiyeResearch and clinical trials
6 patients with ichthyosis from Rize and Istanbul: the skin disease may also affect immunity
A study published in a journal and reviewed by independent scientists. Even so, a single study is not conclusive; it needs to be replicated.
In Rize and Istanbul, 6 patients with ichthyosis due to the ALOX12B gene were studied. The patients came from three families with consanguineous (blood-relative) marriages. Five patients had recurrent bacterial or fungal infections. Four patients had very high IgE levels. One new gene change was found.
What does it mean for patients and families?
Immune tests may be requested for children with ichthyosis who get frequent infections. Dermatologists, immunologists and geneticists should follow these children together. This is a very small study.
Source
Scientific paper: Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis. Frontiers in Immunology, 2025. DOI: 10.3389/fimmu.2025.1662858 · PubMed 41346588
The source page was opened and read on October 7, 2026. Summary prepared by the Doktorclub editorial team and translated from Turkish; it has not yet been reviewed by a physician (a scientific board is being set up).
This page is translated from the Turkish original.
Related disease: Autosomal recessive congenital ichthyosis (ARCI)
This page reports a development; it is not a treatment recommendation. Your doctor decides whether a treatment is right for you.