TürkiyeResearch and clinical trials
Low-dose ACTH for infantile spasms in Istanbul: heart changes without symptoms were seen
A study published in a journal and reviewed by independent scientists. Even so, a single study is not conclusive; it needs to be replicated.
In Istanbul, 24 babies diagnosed with infantile spasms were monitored during low-dose ACTH treatment. The babies' hearts were examined regularly with ECG and advanced echocardiography. None of the babies developed a rhythm disorder or high blood pressure. However, changes without symptoms were found in measurements of the heart's electrical activity and contraction.
What does it mean for patients and families?
ACTH remains an effective first treatment for this disease. The researchers recommend heart checks during treatment. Be sure to discuss treatment decisions with your pediatric neurologist.
Source
Scientific paper: Cardiac safety of low-dose ACTH therapy in infantile spasms: Evidence from electrocardiography and advanced echocardiography. Seizure, 2025. DOI: 10.1016/j.seizure.2025.10.020 · PubMed 41240742
The source page was opened and read on October 7, 2026. Summary prepared by the Doktorclub editorial team and translated from Turkish; it has not yet been reviewed by a physician (a scientific board is being set up).
This page is translated from the Turkish original.
Related disease: West syndrome (infantile spasms)
This page reports a development; it is not a treatment recommendation. Your doctor decides whether a treatment is right for you.