GlobalResearch and clinical trials
Course of 70 patients with advanced PH1: kidney function declined rapidly and the death rate was high
A study published in a journal and reviewed by independent scientists. Even so, a single study is not conclusive; it needs to be replicated.
A total of 70 patients from North America, Europe and the Middle East were studied. The patients' kidney function had fallen below half of normal. In those not on dialysis, kidney function declined every year. 42 patients had a liver or kidney transplant. Of those who did not have a transplant, 39% died. In those who had a transplant, this rate was 19%.
What does it mean for patients and families?
In PH1, early diagnosis and monitoring before kidney loss begins are very important. This is a retrospective study. Treatment options should be discussed with a doctor.
Source
Scientific paper: Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study. Kidney Medicine, 2025. DOI: 10.1016/j.xkme.2025.101115 · PubMed 41209157
The source page was opened and read on October 7, 2026. Summary prepared by the Doktorclub editorial team and translated from Turkish; it has not yet been reviewed by a physician (a scientific board is being set up).
This page is translated from the Turkish original.
Related disease: Primary hyperoxaluria type 1 (PH1)
This page reports a development; it is not a treatment recommendation. Your doctor decides whether a treatment is right for you.