Genetic syndromes and other conditions
A genetic condition with slow growth before and after birth. The baby is born small, and feeding problems are common.
Not part of the panel of Türkiye's National Newborn Screening Programme (heel-prick test). Source
This page is translated from the Turkish original.
This disease is followed through the “Genetic syndromes and other conditions” group.
The setting of the genes that control growth is disturbed. These genes are on chromosomes 11 and 7. In most people the problem is on chromosome 11. In about a third of people, no cause is found.
Symptoms vary from person to person. The following may be seen:
The diagnosis is based on examination findings and a scoring system. Genetic tests look at chromosomes 11 and 7. These tests confirm the diagnosis in about 60 percent of people.
Treatment is planned according to the symptoms and is provided by a team. In the first years the aim is to get enough calories. If needed, a feeding tube is used, but overfeeding is avoided. Blood sugar is monitored. Growth hormone treatment can support height and muscle development. The timing of puberty and bone age are followed by a hormone specialist. If needed, support with speech and movement is given. The doctor who follows the disease decides which treatment is suitable.
In most children the change is new and no one else in the family is affected. Rarely, more than one person in the family is affected. In some families dominant inheritance is seen. The risk depends on the type of genetic change and which parent it comes from. Genetic counselling is recommended.
Source: MedlinePlus Genetics: Silver-Russell syndrome · NORD: Russell-Silver Syndrome
These facts are taken from Orphanet and MedlinePlus records (last checked: October 7, 2026). Frequency values are approximate ranges.
Non-profit patient and family organizations in Türkiye working on this disease or disease group. Links are for information; Doktorclub is not affiliated with these organizations and does not endorse them.
We could not find a patient association specific to this disease.
For all rare diseases: Nadir Hastalıklar Federasyonu
Doktorclub does not diagnose, recommend treatments or refer you to hospitals or doctors. These pages are meant to help you talk with your doctor.
TürkiyeResearch and clinical trials
Pediatric endocrinology centers in Türkiye studied 69 children with Silver-Russell syndrome.
A clinical trial is a regulated study that tests whether a new treatment is safe and whether it works, in patients who volunteer. Most trials look for a certain age, genetic change and health condition. Taking part is voluntary.
ClinicalTrials.gov currently lists no active interventional studies for this disease. Last checked: October 7, 2026.
See all studies on ClinicalTrials.gov · Joining clinical trials
TürkiyeResearch and clinical trials
Ankara University reviewed the brain MRIs of children with Noonan syndrome.
TürkiyeResearch and clinical trials
In Türkiye, 14 centers jointly studied children with Sotos syndrome and the similar Malan syndrome.
FranceResearch and clinical trials
In France, simvastatin was compared with placebo in children with Noonan syndrome.
These codes identify the disease in international classifications and databases. They can help when you talk with your doctor or look for reliable sources.
Orphanet code: ORPHA:813
No separate ICD-11 code; WHO classifies this disease under: LD2F.1Y
Codes checked against WHO ICD-11 and Orphanet on October 7, 2026.
This page provides general information and does not replace diagnosis or treatment. Talk to your doctor about symptoms, diagnosis and treatment.